CELLULAR CHANGES ASSOCIATED WITH HUMAN PAPILLOMAVIRUS
Cytomorphological
Criteria:
•Cellular
changes is caused by oncogenic type of HPV that is commonly from group 16 and
11.
•The
changes can be divided into 2 groups. Which are:
–a)
Classical Changes (CC) – Cellular
changes that occur as a confirmatory criteria of HPV infection
–b)
Non-classical Changes (NCC) - Cellular changes that occur at the early stage of
the HPV infection. May be vary or have little differences from other cellular
changes that caused by other viral infection.
Classical changes:
vKoilocytes – 60 – 70% cases
vKoilocytes is the term used to
classified the cell that has perinuclear halos.
vIn
HPV infection, the infected squamous cells will be seen having cytoplasmic
condensation at the periphery giving hallow central portion.
Non-Classical Changes:
vKoilocytes are hardly be seen.
30 – 20% cases
vSquamous
epithelial cell will appear to have heterogenous cytoplasm , unevenly stained. Mimicking dried smear.
vNuclei
is small and pyknotic- slightly
eccentrically placed
vNuclei
varies from single to bitinucleated due to cytopathic effect.
vHyperchromatic nucleus with
enlargement and eccentrically placed with slight, almost insignificant halos.
In
the figure above, both are from the CP Pap-smear that shows characteristics of
the infection due to HPV. In diagram “a”, the cytoplasm has shown irregularity
of the outline. Besides, the heterogenousity of the nucleus is seen in variety in shapes and colours. Meanwhile in
diagram “b”, the hyperchromatic nucleus is
significantly clear with coarse chromatin. There is also binucleation occur one of the
infected cells marked with “#”.
Hi everyone, 2years ago my doctor told me I was diagnosed with HSV2. I was heart broken, How- ever that same years i found a doctor called Dr ubarlo who helped me to cured the virus with natural herbal treatment per- manently. thanks to Dr ubarlo for his natural herbal treatment that eliminated this virus out in my body forever. his contact of him through Instagram page. for any incur- able virus THESE ARE THE DISEASES CURED BY dr ubarlo 1) HERPES 2) HIV / AIDS 3) lupus 4) CANCER 5) EPILEPSY 6) DIABETES 7) ERECTILE 8) CANCER CURE 9) asthma 10) RIGGING EARS 11) Gout 12) pregnancy 13) Hepatitis ABC 14) Weight loss 15) fibroids you can also contact him on his email drubarlohome@gmail.com or Whatsapp +2348119508814
ReplyDeleteNatural herbs have treated so many illnesses that drugs and injections can't treat. I've seen the great importance of natural herbs and the wonderful work they have done in people's lives. I read people's testimonies online on how they were treated of HSV, HPV, Herpes, Liver diseases, Epilepsy, Fever ,diarrhoea, aches and pains, sore throat , etc , by natural medicine, so I decided to contact the Naturopath Dr because I know nature has the power to heal anything. Believe it or not. but I am a living testimony. There is no harm trying natural herbs. Contact Dr on, text/call via: +1 (719) 629 0982 ,For herbs and medications. Or you can also contact through his Facebook page @ Dr Chike Herbal Remedy.
ReplyDelete